Biochem-707

Biochem-700             CONCEPTS OF BIOCHEMISTRY          3(3-0) 

Learning Objectives

The course aims to provide understanding of the core principles and topics of Biochemistry. It enables students to acquire a specialized knowledge and understanding of basic as well as advanced concepts of biochemistry and related sciences.

Theory

An introduction to Biochemistry and its applications in applied sciences. Introduction to prokaryotic, eukaryotic and archeal cells. Concept of probiotics and prebiotics. Architecture and composition of biomembranes and transportation. Significance and applications of enzymes and co-enzymes. Therapeutic enzymes. Glycobiology, glyco-conjugates and their applications. Tumors and their biomarkers. Programmed cell death.  Metabolic roles of vitamins and minerals. Metabolism of macromolecules and their regulation. Electron transport chain, ATP synthesis. Photosynthesis. Photorespiration and C₄ plants. Energetics of photosynthesis and respiration. Secondary metabolites of plants and their role as bioactive compounds. Biosignalling. Structure of nucleic acids. Flow of genetic information. Post transcriptional and post translational modifications. Protein folding and misfolding. Protein targeting. Introduction to gene cloning. Genetic engineering and genetically modified organisms. Introduction to bioinformatics and omics (Genomics, Transcripteomics, Proteomics, Metabolomics). Introduction to nanobiotechnology and its applications.

Suggested Readings

1. Chatterjea, M. N. and R. Shinde. 2011. Textbook of Medical Biochemistry. 8^th ed (Indian edition). Jaypee Brothers, Medical Publishers (P) Ltd, New Delhi, India.
2. Champe, P.C., R.A. Harvey and D.R. Ferrier. 2014. Biochemistry: Lippincott’s Illustrated Reviews. 6^th Lippincott Williams and Wilkins. U.S.A.
3. Goodwin, T.W. and E.I.Mercer.2003. Introduction to Plant Biochemistry, 2^nd CBS publishers and distributors. New Delhi. India
4. Kaufmann, P.B. and W.Wu, L.J. Creke. 2011. Handbook of   Molecular   and   Cellular   Methods   in   Biology   and Medicines, 3^rd, CRC Press.
5. Nelson, D.L and M.M. Cox. 2013. Lehninger Principles of Biochemistry. 6^th Worth Publishers, New York, NY, USA.
6. Taiz, L. and E. Zeiger. 2015. Plant Physiology 6^th Sinauer Associates Inc., USA.
7. Voet, D. J.G. Voet and C. W. Pratt. 2011. Fundamentals of Biochemistry. 4^th John Wiley and Sons. Inc. New York, NY, USA.
8. Weaver, R. F. 2012. Molecular Biology. 5^th ed. McGraw Hill Higher Education.